Asynchronous Switching Control of Discrete-time Linear System Based on Mode-dependent Average Dwell Time

International Journal of Control, Automation and Systems - In this paper, we investigate the problem of asynchronous switching control for discrete-time linear systems with mode-dependent average...     

MSCT多期增强扫描在肾脏透明细胞癌中的诊断价值

目的探讨多排螺旋CT(MSCT)多期增强扫描在肾脏透明细胞癌诊断中的规律性,提高对该肿瘤诊断水平。方法回顾性分析2016年1月~2018年6月14例均经手术切除病理证实为肾脏透明细胞癌患者的CT影像资料,所有病例均行MSCT平扫及多期动态增强扫描。结果14例肾脏透明细胞癌形态大多数呈圆形或者类圆形,瘤体最大径范围1.7cm^11.3cm,平均(4.8±1.4)cm,13例CT平扫时肿瘤密度不均匀,呈等低密度,1例呈等密度;12例出现坏死囊变,钙化1例,伴肾盂、肾盏侵犯2例;动态增强扫描可见12例包膜完整,1例均匀性强化,13例不均匀性强化;引入对比剂后皮质期,出现10例病灶强化幅度大于肾皮质,而仅4例低于肾皮质,三期平均CT值分别为110±30Hu,90±15Hu及75±14Hu,其中在实质期出现13例肿瘤强化幅度小于肾实质,仅1例大于肾实质。结论引入对比剂动态增强扫描后,肾脏透明细胞癌在皮质期明显不均匀强化,实质期强化幅度下降显著,呈现出典型的“快进快出”血流动力学强化方式,且肿瘤容易出现坏死、囊变为其特点。     

Excellent Mechanical and Transparency Properties of Cationic Waterborne Polyurethane Films Modified by Boehmite Sol

The strategies for nanosol from metal alkoxide have enabled production of ultratransparent and mechanically robust polymer nanocomposites at extremely high loading. Herein, a simple approach to fabricate high‐performance polyurethane‐based nanocomposites via unmodified boehmite nanoparticles is reported. Evaluating their physical properties, the uniform dispersion of boehmite in the matrix caused nanocomposites retains ultrahigh transparency. Hydrogen bonding and intermolecular entanglement between boehmite and polyurethane brings about the mechanical properties of the nanocomposites material enhanced, i.e., strength, stiffness, and toughness. Optimized strength, stiffness, and toughness of Boehmite/Cationic waterborne polyurethane at 40 wt% (BNC40) are up to 58.1 MPa, 1096.7 MPa, 249.5 MJ m^?3, respectively. Furthermore, the feasibility and mechanism of polymer strengthening and toughening by inorganic rigid nanoparticles is explored from the aspects of crystallinity and micromorphology.     

焊缝表面缺陷激光扫描三维重构测量

为检测工件焊缝表面缺陷，采用点激光位移传感测距法和数据拟合技术进行焊缝表面缺陷检测试验研究. 首先采集缺陷表面轮廓数据点，利用高斯滤波对原始数据降噪处理. 再对处理后的数据点进行Delaunay三角剖分，使散乱点连接并结合其空间坐标重构出缺陷的三维模型. 结果表明，基于点激光位移传感测距技术及焊缝表面缺陷三维重构方法可以准确判断焊缝成形情况.     

A Dual Inhibitor of DYRK1A and GSK3β for β-Cell Proliferation: Aminopyrazine Derivative GNF4877

Loss of β-cell mass and function can lead to insufficient insulin levels and ultimately to hyperglycemia and diabetes mellitus. The mainstream treatment approach involves regulation of insulin levels; however, approaches intended to increase β-cell mass are less developed. Promoting β-cell proliferation with low-molecular-weight inhibitors of dual-specificity tyrosine-regulated kinase 1A (DYRK1A) offers the potential to treat diabetes with oral therapies by restoring β-cell mass, insulin content and glycemic control. GNF4877, a potent dual inhibitor of DYRK1A and glycogen synthase kinase 3β (GSK3β) was previously reported to induce primary human β-cell proliferation in vitro and in vivo. Herein, we describe the lead optimization that lead to the identification of GNF4877 from an aminopyrazine hit identified in a phenotypic high-throughput screening campaign measuring β-cell proliferation.     

煤矿新型让压锚杆研究及应用

针对高应力软岩巷道围岩的大变形特征,设计了一种煤矿新型让压锚杆,主要运用钢套管内部约束热固性聚氨酯弹性材料来达到大变形让压的目的。试验表明,该锚杆与传统让压锚杆相比,具有让压距离大(为传统让压锚杆的3倍)、让压后承载性能稳定的显著特点。工程应用表明,该锚杆对深部高应力软岩巷道围岩稳定性能起到较好的控制作用。     

正压给水的主排水泵启动特性仿真分析研究

峰峰集团某矿排水系统在采用正压给水方式后主排水泵泵效明显提高,为了研究排水系统的启动特性,利用Flowmaster软件建立了离心泵串联系统模型。根据水力机械试验室的设备参数进行了仿真,分析了正压给水条件下主泵定量启动前由单泵和双泵组成的排水系统特性。在此基础上,得到了离心泵瞬时启动转速和功率的特性曲线。结果表明,在正压给水条件下,主泵启动功率的影响基本消除,主泵功率达到稳定值的时间缩短。提高了主排水泵的效率,提高了排水系统的综合效率。     

Headspace fingerprinting approach to identify the major pathway influencing volatile patterns of vinasse-cured duck processed by high pressure,as well as its impact on physicochemical and sensory attributes

As a decisive attribute, flavour could be influenced by HP treatments through multiple physical and chemical pathways within the high pressure (HP)-assisted meat curing process. This investigation aimed to identify the major pathway influencing volatile flavour patterns of two representative vinasse-cured duck (VCD) products with HP treatments (150–300 MPa/15 min), including wet and dry types, by employing headspace fingerprinting as an untargeted approach. Results suggested that HP treatments greatly lowered moisture contents and increased Warner-Bratzler shear force and thiobarbituric acid reactive substances of the cured samples. According to multivariate models, the volatile flavour patterns of the HP-processed VCD could be clearly separated from the unprocessed samples, but the VCD pressurised at different intensities represented similar volatile fingerprinting, which was validated by e-nose analysis. The discriminant analysis (OPLS-DA) model outlined vinasse-derived ethanol, acetic acid, 3-methyl-1-butanol, 2-methyl-1-butanol, phenethyl alcohol and 2-methyl-3-octanone as the major discriminant aromas across the unpressurised and pressurised samples.